Preclinical Toxicity Evaluation of Quassia amara Extract with Potential Antimycobacterial Activity
نویسندگان
چکیده
منابع مشابه
Reproductive Toxicity of Quassia amara Extract: Action on Sperm Capacitation and Acrosome Reaction
Quassia amara is a medicinal plant with several pharmacological properties. There are preliminary reports implicating this plant in male reproductive toxicology. Single daily oral administration of methanol extract of Quassia amara stem bark for 6 weeks resulted in a significant reduction in the weight of the testes, caudal epididymis and seminal vescicle. Caudal epididymal sperm parameters sho...
متن کاملPhagodeterrence by Quassia amara (Simaroubaceae) wood extract fractions on Hypsipyla grandella (Lepidoptera: Pyralidae) larvae.
In Latin America and the Caribbean, precious wood species like mahoganies (Swietenia spp.) and cedars (Cedrela spp.) are seriously injured by the mahogany shootborer, Hypsipyla grandella (Zeller) (Lepidoptera: Pyralidae) larva, which bores into the main shoot of trees. In previous experiments focused on searching for a preventive method for managing this pest, a wood extract of bitterwood, Quas...
متن کاملReproductive activities of female albino rats treated with quassin, a bioactive triterpenoid from stem bark extract of Quassia amara.
To evaluate the effect of quassin on female reproductive functions, 42 albino rats (35 females and 7 males) were used. The female albino rats were divided into seven groups of five rats each. Group I served as the control group and received distilled water while Groups II, III and IV rats were treatedorally with 0.1mg/kg, 1.0 mg/kg and 2.0 mg/kg body weight of quassin for 60 days respectively. ...
متن کاملAntimalarial activity of simalikalactone E, a new quassinoid from Quassia amara L. (Simaroubaceae).
We report the isolation and identification of a new quassinoid named simalikalactone E (SkE), extracted from a widely used Amazonian antimalarial remedy made out of Quassia amara L. (Simaroubaceae) leaves. This new molecule inhibited the growth of Plasmodium falciparum cultured in vitro by 50%, in the concentration range from 24 to 68 nM, independently of the strain sensitivity to chloroquine. ...
متن کاملAntifertility activity of Quassia amara in male rats - in vivo study.
The crude methanol extract of the stem wood of Quassia amara. L. (A-1) significantly caused a reduction in the weight of the testis, epididymis and seminal vesicle, but an increase in that of the anterior pituitary gland. Epididymal sperm counts, serum levels of testosterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH) were significantly reduced when the rats were treated wi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Bioanalysis & Biomedicine
سال: 2012
ISSN: 1948-593X
DOI: 10.4172/1948-593x.s5-004